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. 2017 Jan 4;8(9):15441–15452. doi: 10.18632/oncotarget.14487

Figure 3. L1 increases chemoresistance of retinoblastoma.

Figure 3

A and B. The cell viability of control and L1-depleted Y79 cells (A) or control and L1-overexpressing SNUOT-Rb1 cells (B) upon the treatment with carboplatin, vincristine, and etoposide. C. The expression of 35 proteins associated with apoptosis in control and L1-depleted Y79 cells on antibody array. Significantly up-regulated or down-regulated proteins were shown below. D. The expression of Bcl-2, Bcl-xL, cleaved caspase-3, cytochrome-c in control and L1-depleted Y79 cells upon the treatment with carboplatin, vincristine, and etoposide on Western blot analyses. Control, Y79 cells or SNUOT-Rb1 cells; shL1, Y79 cells transfected with L1-specific shRNA; L1 OE, SNUOT-Rb1 cells transfected with a lentiviral vector containing full length L1. Cas-3, caspase-3. Bars, SEM. *, P < 0.05; NS, P > 0.05 (Unpaired T-test).