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. 2017 Jan 17;8(9):15520–15538. doi: 10.18632/oncotarget.14690

Figure 6. MC3181 inhibits WM266.4 spheroids invasion into type I collagen.

Figure 6

3D melanoma spheroids were embedded in a collagen matrix and treated with 0.04, 0.20 and 1.0 μM MC3181. The distance invaded by WM266.4 cells was monitored by phase contrast imaging (10X magnification, 3X digital magnification), over a 48 hours incubation period. Scale bar: 100 μm. The graph shows the mean distance invaded by spheroids ± SD; sample number: n = 10 for every condition; *P < 0.05, **P < 0.005 and ***P < 0.0005 vs the respective time-matched control.