A. Univariate analysis.
| Variables | Recurrence-free survival | Overall survival | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| Age | (> 50 vs. ≤ 50) | 1.1 | 0.5−2.3 | 0.85 | 1.2 | 0.6−3.1 | 0.62 |
| Tumor size | (> 2 cm vs. ≤ 2 cm) | 2.7 | 1.5−5.1 | 0.0015 | 2.6 | 1.3−5.3 | 0.0075 |
| Nodal status | (Positive vs. Negative) | 2.8 | 1.5−5.1 | 0.0011 | 2.1 | 1.1−4.3 | 0.032 |
| Nuclear grade | (3 vs. 1 and 2) | 1.0 | 0.5−2.1 | 0.99 | 0.7 | 0.4−1.6 | 0.44 |
| Ki-67 | (> 30% vs. ≤ 30%) | 1.8 | 0.8−5.2 | 0.21 | 1.2 | 0.5−3.2 | 0.72 |
| PD-L1 | (Positive vs. Negative) | 0.8 | 0.4−1.5 | 0.56 | 0.6 | 0.3−1.2 | 0.13 |
| PD-L1IC | (Positive vs. Negative) | 0.6 | 0.3−1.1 | 0.09 | 0.7 | 0.4-1.4 | 0.35 |
| TILs | (High vs. Low) | 0.8 | 0.4−1.5 | 0.55 | 0.4 | 0.2−0.8 | 0.015 |
| PD-L1*TILs | (PD-L1+/TILs-Low vs. PD-L1+/TILs-High) | 4.7 | 1.6−12.7 | 0.0067 | 8.4 | 2.3−30.3 | 0.0019 |
| (PD-L1–/TILs-High vs. PD-L1+/TILs-High) | 2.8 | 1.1−6.9 | 0.031 | 3.1 | 0.9−11.1 | 0.083 | |
| (PD-L1–/TILs-Low vs. PD-L1+/TILs-High) | 1.4 | 0.7−3.2 | 0.38 | 3.2 | 1.3−9.7 | 0.013 | |