Figure 1. Endotoxemia results in greater and sustained left ventricular functional injury in aging mice.

Adult and aging mice were treated with lipopolysaccharide (LPS, 0.5 mg/kg, iv) or normal saline. Left ventricular (LV) pressure-volume loops were analyzed at 24 and 48 h after treatment. A. Representative pressure-volume loops show that aging mice display a greater reduction in LV performance. B. LV function data show that aging mice have lower developed pressure, ejection fraction and cardiac output after treatment with LPS. Data are expressed as mean ± SE. n=8, *P<0.05 vs. control, ^#P<0.05 vs. the same time point in adult.