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. 2017 Feb 1;8(9):15663–15676. doi: 10.18632/oncotarget.14933

Figure 4. Treatment with recombinant Klotho after injection of LPS preserves myocardial HSP70 levels and improves cardiac function in aging mice.

Figure 4

Recombinant Klotho (10 μg/kg, iv) was administered 30 min after injection of lipopolysaccharide (LPS, 0.5 mg/kg, iv) in aging mice. Myocardial HSP70 levels were analyzed with immunoblotting, and LV pressure-volume loops were analyzed at 24 and 48 h after treatment with LPS. A. Representative immunoblot and densitometric data show that HSP70 levels are higher in aging mice treated with recombinant Klotho than those in aging mice treated with normal saline. B. LV function indices in aging mice are improved by the treatment with recombinant Klotho. Data are expressed as mean ± SE. n=6, *P<0.05 vs. control, #P<0.05 vs. LPS+saline.