Table 1. Myocardial chemokine and cytokine levels are higher in aging endotoxemic mice.
Cytokines | Adult | Aging | ||||
---|---|---|---|---|---|---|
Control | LPS 24 h | LPS 48 h | Control | LPS 24 h | LPS 48 h | |
MCP-1 (ng/mg) | 80.8±16 | 328±31* | 150±24* | 104±21 | 804±88*# | 399±78*# |
KC (ng/mg) | 81.6±24 | 501±79* | 286±69* | 93.8±17 | 1205±36*# | 743±41*# |
IL-6 (ng/mg) | 71.4±9.5 | 264±18* | 151±14* | 83.8±5.4 | 493±30*# | 345±21*# |
IL-1β (pg/mg) | 78.1±10 | 292±50* | 152±35* | 88.4±15 | 668±61*# | 397±55*# |
TNF-α (pg/mg) | 15.3±5.1 | 160±32* | 77±23* | 19.3±4.4 | 387±43*# | 278±29*# |
Data are expressed as mean ± SE. n=8 in each of the 6 groups; *P<0.05 vs. control; #P<0.05 vs. the same time point in adult