Table 3. Treatment with recombinant Klotho decreases myocardial cytokine and chemokine levels in aging endotoxemic mice.
| Cytokines | With Saline | With Klotho | ||||
|---|---|---|---|---|---|---|
| Control | LPS 24 h | LPS 48 h | Control | LPS 24 h | LPS 48 h | |
| MCP-1 (ng/mg) | 110±11 | 864±148* | 450±84* | 106±23 | 491±42*# | 268±69*# |
| KC (ng/mg) | 94.5±7.1 | 1214±195* | 743±104* | 98.2±17 | 752±37*# | 434±46*# |
| IL-6 (ng/mg) | 81.8±4.7 | 468±52* | 356±23* | 78.8±10 | 375±23*# | 260±31*# |
| IL-1β (pg/mg) | 93.4±6.1 | 677±57* | 417±35* | 89.8±18 | 453±13*# | 287±27*# |
| TNF-α (pg/mg) | 20.1±2.7 | 439±69* | 260±27* | 22.3±6.4 | 260±21*# | 157±17*# |
Data are expressed as mean ± SE. n=6 in each of the 6 groups; *P<0.05 vs. control; #P<0.05 vs. LPS+saline