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SerpinB3 determines an increase of β-Catenin. The accumulation of β-Catenin in the nucleus interacts with T-cell factor (TCF) and lymphoid enhancer binding protein (LEF) transcription factors to activate COX-2 gene. The COX-2 protein in turn increases PGE2 levels and these two molecules strengthen the positive loop of β-Catenin/LEF1/TCF-mediated transcription.
