Figure 4. Combination of TMZ and BI2536 leads to a marked tumor regression in IDH1 mutant tumors.

A. Average subcutaneous tumor volumes of vehicle, TMZ, BI2536, and TMZ+BI2536-treated mice over 28 days. B. Representative images of excised subcutaneous tumors 31 days after treatment began. Scale bars=1cm. Error bars represent SEM. P<0.001 (***). n≥5 mice per treatment group.