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. 2016 Dec 26;8(9):16075–16083. doi: 10.18632/oncotarget.14211

Figure 2. Functional mechanisms of lncRNAs in NPC.

Figure 2

A. Hotair promoted angiogenesis through directly activating the transcription of angiogenic factor VEGFA as well as through GRP78-mediated upregulation of VEGFA and Ang2 expression. B. AFAP1-AS1 inhibits AFAP1 protein expression and affected the expression of several small GTPase family members and molecules in the actin cytokeratin signaling pathway. promoted cancer cell metastasis via regulation of actin filament integrity. C. XIST functioned as an oncogene in NPC through up-regulating E2F3 in part through ‘spongeing’ miR-34a-5p. D. H19 Inhibits E-cadherin expression and promoted invasion via the mir-630/EZH2 pathway. E. MALAT1 regulates CSC activity and radioresistance by modulating mir-1/slug axis. F. NEAT1 regulates EMT phenotype and radioresistance by modulatin themir-204/ZEB1 axis.