Fig. 2.

Details of the patient divided into three main groups: clinical symptoms, diagnostic interventions, and lab monitoring. In the top in differently colored bars, the clinical manifestations of the disease in the patient are depicted. Below another bar shows the pre-study period followed by the SAM trial. The dotted black line indicates the adjustments of allopurinol therapy. A small drop in uric acid concentrations can be seen after start of allopurinol therapy, but the dose had to be adapted several times until urine and blood uric acid decreased to therapeutic ranges, while urinary xanthine and hypoxanthine increased