Table 1.

Distinct pathways involved in different stages of withdrawal after chronic cocaine treatment.

2 h after final cocaine administration
#	Pathway	FDR	Pathway ID
1	Pathways in cancer	0.005854	ko05200
2	Circadian rhythm - mammal	0.005854	ko04710
3	Adherens junction	0.006437	ko04520
4	Circadian rhythm - fly	0.011379	ko04711
5	Jak-STAT signaling pathway	0.011575	ko04630
6	Melanogenesis	0.029236	ko04916
7	Wnt signaling pathway	0.029236	ko04310
8	MAPK signaling pathway	0.029236	ko04010
24 h after final cocaine administration
#	Pathway	FDR	Pathway ID
1	Circadian rhythm - mammal	0.00279	ko04710
2	MAPK signaling pathway	0.013751	ko04010
3	Circadian rhythm - fly	0.030747	ko04711
7 days after final cocaine administration
#	Pathway	FDR	Pathway ID
1	Oxidative phosphorylation	4.86E-32	ko00190
2	Ribosome	3.71E-31	ko03010
3	Parkinson's disease	5.02E-27	ko05012
4	Huntington's disease	1.70E-26	ko05016
5	Alzheimer's disease	2.96E-24	ko05010
6	Proteasome	2.00E-07	ko03050
7	Cardiac muscle contraction	3.95E-06	ko04260
8	Vibrio cholerae infection	2.19E-05	ko05110
9	Metabolic pathways	2.63E-05	ko01100
10	Rheumatoid arthritis	0.001783	ko05323
11	Epithelial cell signaling in Helicobacter pylori infection	0.001876	ko05120
12	Collecting duct acid secretion	0.004512	ko04966
13	RNA polymerase	0.007616	ko03020
14	Citrate cycle (TCA cycle)	0.008566	ko00020
15	Protein export	0.009591	ko03060
16	Gastric acid secretion	0.011006	ko04971
17	Salivary secretion	0.015994	ko04970
18	Vascular smooth muscle contraction	0.016231	ko04270
19	Aldosterone-regulated sodium reabsorption	0.028328	ko04960
20	Long-term potentiation	0.035467	ko04720

*FDR mean “false discovery rate.”