FIGURE 4.

ClC-K channels are expressed in kidney and inner ear. (A) At the nephrons, luminal NKCC2 transporters build up Na⁺, K⁺ and Cl^- into the cells. K⁺ flows back to the lumen through ROMK1 channels; Na⁺ and Cl^- are reabsorbed to the bloodstream separately through Na+/K+ ATPase and ClC-Kb channels, respectively. (B) In the Stria Vascularis, Na⁺, K⁺ and Cl^- are transported into the cells by basolateral NKCC1 transporters. Na⁺ and Cl^- are recycled back to the interstitium by Na+/K+ ATPase and both ClC-Ks isomers, respectively. K⁺ flows through KCNQ1/KCNE1 channels and accumulates into the endolymph, a condition required for sensory transduction in inner hair cells.