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. 2017 Apr;24(4):153–157. doi: 10.1101/lm.044578.116

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© 2017 Leake et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Learning & Memory, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — PSI regulates the level of Arc expression in the hippocampal DG/CA3 and CA1 regions. (A) Experiment design. Mice (n = 11 per group) were placed in a novel context for 30, 180, or 720 sec prior to footshock. Naïve home cage controls were included as comparators. Hippocampal DG/CA3 and CA1 fractions were collected 60 min post-conditioning and probed for Arc and β-actin immunoreactivity. Arc levels increased as a function of PSI in the DG/CA3 (B) and the CA1 (C) regions. Data were collected from three experiments with similar results. Data are presented as mean + SE. Significance is indicated by (*) P < 0.05, (**) P < 0.01, (***) P < 0.001. No statistical difference is indicated by n.s.