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Reduction of (A) tumor volume and (B) tumor weight versus vehicle-treated controls after chronic oral dosing (30 mg/kg q.d.) of 109 to an APC-mutant SW620 human colorectal carcinoma xenograft animal model. (C) Free plasma and free tumor exposure (nM) at 1, 2, 6, and 24 h after the last dose in the same experiment.
