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. 2016 Jan 21;59(3):1078–1101. doi: 10.1021/acs.jmedchem.5b01685

Table 10. Potency of 6 and 109 versus Reporter-Based Readouts of WNT Pathway Activity in Human Cancer Cell Lines.

cell line WNT pathway activation 6 IC50 (nM) 109 IC50 (nM)
LS174T β-catenin mutant 23 ± 11 33 ± 13
SW480 APC-mutant 190 ± 30 22 ± 2
Colo205 APC-mutant 35 ± 3 15 ± 1
PA-1 WNT ligand-dependent 20 ± 10 64 ± 34