Table 10. Potency of 6 and 109 versus Reporter-Based Readouts of WNT Pathway Activity in Human Cancer Cell Lines.
cell line | WNT pathway activation | 6 IC50 (nM) | 109 IC50 (nM) |
---|---|---|---|
LS174T | β-catenin mutant | 23 ± 11 | 33 ± 13 |
SW480 | APC-mutant | 190 ± 30 | 22 ± 2 |
Colo205 | APC-mutant | 35 ± 3 | 15 ± 1 |
PA-1 | WNT ligand-dependent | 20 ± 10 | 64 ± 34 |