Table 6. Pharmacokinetic Profile of a Set of Compounds in Wild-Type and P-gp KO Mice.

			wild type mice		P-gp KO mice
	ER Caco-2	mouse Clint (μL/min/mg)	plasma Cl (L/h/kg)	parent compd in feces (%)	plasma Cl (L/h/kg)	parent compd in feces (%)
6	2.5	141	2.34	9.1	2.30	<1
89	2.0	18.5	2.59	17	2.84	<1
42	4.7	57	4.89	18	4.00	<1
90	14.8	<10	4.08	20	2.85	<1
48	17.6	30	4.43	67	2.22	24