Table 7. Attempts To Reduce Efflux in the Pyridine Series^d.

^aFree base.

^bTFA salt.

^cIn this case the chloro substituent is at C-5 according to nomenclature 8-(3-(3-amino-1-methyl-1H-indazol-6-yl)-5-chloropyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one.

^dM: mouse. R: rat. H: human. log P was calculated using Percepta Batch, version 2015 (www.acdlabs.com). TPSA was calculated in the program MOE (www.chemcomp.com).