Figure 2.

Comparative enrichment analysis of microRNA for Pathway Maps, Gene Ontology, Disease by Biomarker, and Network Processes. MetaCore pathway analysis of small RNA-sequencing data from the tumor and metastatic cancer samples were uploaded to MetaCore servers and most significantly affected pathways analyzed. A: Pathway Maps: Canonical pathway maps were generated, where three out of the top four pathways are involved in colorectal cancer pathogenesis (regulation of miRNAs, role of miRNAs in cell proliferation; and role of miRNAs in migration, survival and angiogenesis). B: Geno Ontology: GO processes were analyzed illustrating that gene silencing of miRNA and post transcriptional gene silencing most impacted. C: Disease status: Significantly involved miRNAs in disease were listed; most of the miRNAs were involved in adenocarcinomas. D: Comparative enrichment analysis: Differential expression of miRNAs in disease groups.