Table 2. NACT, adjuvant chemotherapy, and toxicity.
| Variable | No. (%) of patients | ||
|---|---|---|---|
| NACT | Adjuvant | ||
| Chemotherapy | |||
| Median number of cycles | 3 | 3 | |
| Dose reductions required | 32/268 (11.9) | 20/268 (7.4) | |
| Toxicity (grade 3 or 4*) | |||
| Diarrhea | 30/268 (11.2) | 6/200 (3.0) | |
| Vomiting | 16/268 (6.0) | 5/200 (2.5) | |
| Hand-foot syndrome | 11/268 (4.1) | 3/200 (1.5) | |
| Mucositis | 5/268 (1.9) | 0/200 (0.0) | |
| Neutropenia | 8/268 (3.0) | 2/200 (1.0) | |
| Thrombocytopenia | 7/268 (2.6) | 1/200 (0.5) | |
| Anemia | 2/268 (0.7) | 0/200 (0.0) | |
| Febrile neutropenia | 2/268 (0.7) | 0/200 (0.0) | |
| Neuropathy | 2/268 (0.7) | 0/200 (0.0) | |
| Hyponatremia | 3/268 (1.1) | 1/200 (0.5) | |
| Non-neutropenic sepsis | 3/268 (1.1) | 0/200 (0.0) | |
Values are presented as median or number (%).
NACT = neoadjuvant chemotherapy.
*Classification according to the Common Terminology Criteria for Adverse Events (CTCAE) 4.03_2010-06-14.