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. 2017 Mar 23;7:45155. doi: 10.1038/srep45155

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(A) Intracellular Ca²⁺ in the cells under cold conditions (4 °C). The Ca²⁺ concentration in the cytoplasm at 4 °C is higher than that at 37 °C. (B) The mRNA expression levels of TRPM8, TRPA1, NFκB and TNFα. (C,D) The protein expression levels of TRPM8, TRPA1, NFκB and TNFα. Data are shown as the mean ± S.D. from three experiments. ^#P < 0.05; ^##P < 0.01, v.s. the control (zero time).