Table 3. Associations of PIGD severity with the levels of Aβ_1–42 and P-tau181t in CSF in univariate and multivariate linear regression models with adjustment for potential confounders.

Variable	Univariate		Multivariate
	β	P value	β	P value	β	P value
Age (years)	0.181	0.000**	0.009	0.876	0.640	0.893
Age of onset (years)	0.049	0.253	−0.032	0.923	−0.020	0.803
Sex (male/total, %)	−0.007	0.859	−0.288	0.422	0.057	0.883
Education (N, %)	−0.092	0.030*	0.022	0.945	0.342	0.311
Predominantly affected side	0.008	0.861	−0.240	0.395	0.018	0.73
MoCA (scores)	−0.231	0.000**	−0.066	0.048*	0.037	0.047*
Disease duration (years)	0.300	0.000**	0.126	0.288	0.059	0.624
Hoehn-Yahr stage (stage)	0.653	0.000**	2.130	0.000**	2.247	0.000**
Aβ1–42 in CSF (ng/ml)	−0.221	0.018*	−1.178	0.014*	—	—
P-tau181t in CSF (pg/ml)	0.224	0.000**	—	—	0.018	0.012*

MoCA = Montreal Cognitive Assessment; Aβ_1–42 = β amyloid (Aβ)_1–42; P-tau181t = tau phosphorylated at threonine 181. *P < 0.05, **P < 0.01.