Table 1.
Cytotoxicity of well-characterized human nephrotoxicants in HK-2 and SA7K Cells.
| Nephrotoxicants | Cell viability (IC50, µM) | Caspase 3/7 (EC50, µM) | MMP (IC50, µM) | |||
|---|---|---|---|---|---|---|
| HK-2 | SA7K | HK-2 | SA7K | HK-2 | SA7K | |
| Cyclosporine A | 19.92±4.17 | Inactive | Inactive | 11.12±1.80 | Inactive | 10.34±1.86 |
| Potassium dichromate | 65.75±14.83 | 18.65±5.27 | Inactive | 23.39±1.90 | Inactive | 72.54±4.91 |
| Cadmium (II) chloride | 26.98±4.60 | 65.23±11.73 | Inactive | Inactive | Inactive | Inactive |
| Citrinin | 78.2±0 | 87.75±0 | Inactive | 98.46± 0 | 78.56±9.03 | 73.96±6.01 |
| Adefovir dipivoxil | 64.65±4.38 | 91.71±11.69 | 63.23±14.46 | 84.57±5.51 | Inactive | 78.21±0 |
| Puromycin | 1.30±0.64 | 3.95±0.64 | 3.37±0.22 | 2.55±0.82 | Inactive | 5.28±2.68 |
| Arsenic trioxide | 13.15±1.07 | 17.19±4.29 | Inactive | 15.16±6.0 | Inactive | Inactive |
| Rifampin | 84.57±5.51 | 69.70±0 | Inactive | 82.98±6.75 | 26.89±3.70 | 15.67±5.70 |
| Tacrolimus | Inactive | Inactive | Inactive | Inactive | 49.93±0 | 22.30±0 |
| Tetracycline | Inactive | Inactive | Inactive | Inactive | Inactive | 9.85±0 |
Data are presented as mean ± SD from two to three experiments. Compounds showing no concentration response were defined as inactive.