Table 2.

ctDNA and tumor markers measurements in 8 breast cancer patients with stage IV disease

Patient	Tracked mutation	Sample	Target/Total	mutated copies/mL	CA 15.3 (U/ml)	CEA (ng/ml)	Figure
25	H1047R	March 07 2014	18.36%	54398	97	27	Additional file 4: Figure S1
		Oct 13 2014	0.11%	12.1	32.8	7.1
		Nov 03 2014	0%	0	32.3	7.5
44	H1047R	Aug 29 2014	1.78%	310.5	126	1.6	Fig. 1b
		Sep 17 2014	1.85%	975	997.2	5.2
		Oct 23 2014	2.08%	1203.2	1219	11.6
		Nov 19 2014	0.81%	102.9	487.3	4.8
15	H1047R	Feb 18 2014	0.36%	24.7	68.9	4.7	Additional file 4: Figure S3
		May 29 2014	0.32%	30.6	58.6	4.3
		Aug 27 2014	0.03%	25.6	39.4	3.3
2	H1047R	Dec 03 2013	2.39%	149.6	96.8	5.7	Fig. 1a
		Jan 02 2014	3.93%	77.3	91.6	12.7
		Jan 30 2014	4.39%	3082.1	100.6	13.9
		March 03 2014	9.61%	3629.3	138.1	19.8
31	H1047R	March 27 2014	0.19%	13.5	89.3	22.1	Fig. 1c
		Aug 29 2014	0%	0	30.7	6.2
		Oct 02 2014	0%	0	28.8	5.1
		Nov 03 2014	0%	0	17.5	4.4
11	E545K	March 06 2014	27.19%	9274.2	86	108	Additional file 4: Figure S2
		April 09 2014	6.61%	235.9	66	86
3	E545K	Dec 02 2013	4.23%	412.5	57.6	2.8	Fig. 2
		March 12 2014	3.07%	1839.5	60.8	3
		Sep 10 2014	1.97%	165.1	114.6	15.1
		Dec 15 2014	0.76%	143.5	179.5	9
6	E542K	Feb 10 2014	0.24%	63.30	115.6	3.9	Additional file 4: Figure S4
		Apr 04 2014	0%	0	88.5	2.9
		Sep 05 2014	0%	0	45	1.7