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. 2017 Mar 23;9:27. doi: 10.1186/s13073-017-0417-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Evidence for alternative activation of MØs in SSc-PF lung that is distinct from SSc skin. a Genes identified by differential network analysis and inferred to be indicative of lung-resident MØs are correlated with canonical markers of alternatively activated MØs such as CCL18 and CD163 in the Christmann dataset. b Summarized expression values (mean standardized expression value) of gene sets (coexpression modules) upregulated in various MØ states from the Christmann and Hinchcliff datasets: module CL1, classic activation (IFN-γ); modules ALT 1 and 2, alternative activation (IL-4, IL-13); modules FFA 1, 2, and 3, treatment with free fatty acids. FFA free fatty acid. Modules from [34]. Asterisks (*) indicate significant differences (p < 0.05)