Table 4.

Selected pathways that are similar to overlapping coexpression patterns in consensus clusters in the information graph

Consensus cluster	Summary of selected pathways
1A	DNA repair Cell cycle RNA metabolism Transcription
2	Cell–cell junction organization Aquaporin-mediated transport Tight junctions
3A	Endocytosis mRNA processing Metabolism of proteins
4A	T cytotoxic and helper pathway Antigen processing and presentation Allograft rejection
4B	ECM receptor interaction Collagen formation ECM organization TGF-beta signaling Signaling by PDGF
5	G2 M checkpoint Unwinding of DNA Cell cycle
6	Notch signaling Nuclear receptors in lipid metabolism and toxicity
7	Steroid biosynthesis Fatty acid metabolism PPAR signaling pathway
8	Keratin metabolism FGFR ligand binding and activation

We calculated the Jaccard similarity index between edges in the information graph and canonical pathways and used a Mann–Whitney U test to assess whether a particular pathway was more similar to edges within a consensus cluster than outside the consensus cluster