Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary of synthesis and biological activities of Gemini 20S-hydroxyvitamin D3 (20D3) analogs used in this study. The synthesis starts from pregnenolone acetate to obtain 7-dehydrocholesterol intermediates which are then irradiated by UVB to produce D3 structures. These analogs likely exert their activities, including gene up-regulation, antiproliferative and anti-inflammatory effects, through activation of the vitamin D receptor (VDR).
