Figure 7.

Chondrocyte Death in MT-COMP Growth Plates Is Markedly Reduced by COMP-Targeted ASO1

(A–C) TUNEL immunostaining of P29 growth plates from MT-COMP (MT-COMP/COMP^+/+) with and without ASO1 administration mice (B and C). The percentage of TUNEL-positive growth plate chondrocytes is compared (n ≥ 8 mice/group) (A). The percentage of TUNEL-positive MT-COMP growth plate chondrocytes is dramatically reduced by ASO1 treatment from 90% to 19%. Representative images of MT-COMP PBS (B) and ASO1 (C) treated growth plates are also shown. DAPI (blue) was used to visualize nuclei, and the TUNEL signal is shown in green. ***p > 0.0005.