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Diagram of the Current Study
In the AD brain, HDAC2 is upregulated and induces the deacetylation of the HNF-4A transcription factor, which leads to the inhibition of HNF-4A and the suppression of miR-101b expression. The loss of miR-101b induces AMPK overexpression and ultimately results in tauopathy. Data are presented as mean ± SEM.
