Figure 2.

Impairments in Metabolism of Essential, Conditionally Essential, and Non-essential Amino Acids in MPS IIIB Mice during Disease Progress

(A–C) Mouse serum samples were analyzed by global metabolomic profiling using mass spectrometry at the age of 2 or 7 months (n = 6/group). Data are presented as Scaled Intensity (y axis) using whiskers boxplots, based on p ≤ 0.05 IIIB-7 m versus WT-7 m. WT, wild-type mice; IIIB, MPS IIIB mice; AAV9, MPS IIIB mice treated at age 1 month with an i.v. injection of 5 × 10¹²vg/kg rAAV9-CMV-hNAGLU.