Table 1.

Inhibition of factor Xa through the formation of inhibitor 15.^[a]

[a] In the fragment ligation assay, the dipeptide derivatives 1–13 were incubated with 4‐aminomethylbenzamidine (14) in the presence (blue) or absence (red) of the target protein (pH 8, 2 h, 20 °C; see the Supporting Information for details). The active esters 12 and 13 displayed a statistically significant templating effect as determined with an unpaired t‐test yielding p=0.0002.