A2aR (but not A1R) is selectively up-regulated in spinal cord of SOD1G93A mice and post-mortem human ALS samples. A representative immunoblot of A2aR (A), A1R (C) and corresponding quantification (A2aR, B and A1R, D) in lumbar cords of WT and SOD1G93A mice (P100–P110); *, P < 0.05 determined by the Student’s t-test, N = 4–6 mice/sample; N.S.: not significant; A representative immunoblot of A2aR (E) and A1R (F) in spinal cords of post-mortem human ALS patients and controls. G. Quantification in spinal cords of post-mortem human ALS patients and controls; *, P < 0.05 determined by the Student’s t-test, N = 6/group.