Table 1.
Baseline characteristics of patients, by cohort
| Zambia |
Switzerland |
|||||
|---|---|---|---|---|---|---|
| HIV (n=643) | HIV/HBV (n=96) | P | HIV (n=1,965) | HIV/HBV (n=93) | P | |
| General characteristics | ||||||
| Female (%) | 346 (53.8) | 42 (43.8) | 0.07 | 447 (22.8) | 21 (22.6) | 0.97 |
| African origin (%) | 643 (100) | 96 (100) | 0.99 | 306 (15.6) | 25 (26.9) | 0.004 |
| Median age in years (IQR) | 34 (29-41) | 34 (29-39) | 0.30 | 39 (32-46) | 38 (31-45) | 0.38 |
| At-risk alcohol intake (%) | 155 (24.1) | 29 (30.2) | 0.20 | 191 (10.7) | 12 (14.6) | 0.26 |
| Advanced HIV disease (%) | 288 (45.4) | 38 (40.0) | 0.32 | 216 (11.0) | 8 (8.6) | 0.47 |
| Median CD4 in cells/μL (IQR) | 226 (121-330) | 233 (114-361) | 0.59 | 277 (178-381) | 293 (170-413) | 0.64 |
| Median creatinine in μmol/L (IQR) | 80 (70-92) | 79 (70-91) | 0.72 | 76 (66-87) | 75 (64-88) | 0.84 |
| Median platelets in G/L (IQR) | 250 (197-316) | 246 (190-303) | 0.35 | 205 (168-252) | 199 (165-242) | 0.41 |
| Liver-related characteristics | ||||||
| Grade 1 ALT elevation or above (%) | 49 (7.6) | 14 (14.6) | 0.02 | 215 (10.9) | 23 (24.7) | <0.001 |
| Median APRI (IQR) | 0.36 (0.26-0.53) | 0.44 (0.29-0.76) | 0.01 | 0.39 (0.29-0.59) | 0.50 (0.37-0.89) | <0.001 |
| HBV viral load category (%) | ||||||
| <20 | NA | 11 (12.2) | NA | NA | 12 (16.2) | NA |
| 20-19,999 | NA | 40 (44.4) | NA | NA | 29 (39.2) | NA |
| ≥20,000 | NA | 39 (43.3) | NA | NA | 33 (44.6) | NA |
NA: not applicable