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. 2017 Jan 11;4:169–177. doi: 10.1016/j.omtm.2017.01.001

Figure 5.

Figure 5

CXCL12 Restores Uterine Function

Pregnancy outcomes among control and treated female groups were determined by mating with fertile wild-type males. Pregnancy rate is not significantly reduced in this mild AS model. However, blocking the ability of endogenous CXCL12 to spontaneously repair the uterus after injury by administration of AMD3100 did reduce pregnancy rate. Litter size and time to conceive are both significantly affected by injury in this model. CXCL12 treatment restored litter size and time to conceive. AMD3100 treatment blocked the effects of supplemental CXCL12. AMD3100 reduced pregnancy rate and litter size as well as increased time needed to conceive in this AS model. *p < 0.05, **p < 0.01 versus Control; #p < 0.05, ##p < 0.001 versus AS plus PBS; †p < 0.05, ††p < 0.01, and †††p < 0.001 versus AS plus CXCL12. Data are presented as mean ± SEM.