Figure 3.
DZNep Alters Expression of Numerous Genes in a Chronic Model of CCl4-Induced Liver Fibrosis
(A) A heatmap displaying results of microarray carried out using four control and four DZNep-treated livers from a chronic model of CCl4-induced liver fibrosis. The top 15 most upregulated and downregulated genes are shown. Blue, negative values (i.e., downregulated); red, positive (upregulated); yellow, unchanged. (B) mRNA level of Slpi and (C) Hamp2, G6pc, and Thrsp genes was quantified by qPCR in order to validate the results of microarray. Error bars in relevant panels represent mean ± SEM. **p < 0.01; ***p < 0.001.