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. 2017 Jan 4;25(1):218–231. doi: 10.1016/j.ymthe.2016.10.004

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© 2017 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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DZNep Inhibition of Histone Methylation Is Not Specific to H3K27me3

(A) 30 μg whole-cell protein from six livers of control animals or six livers from DZNep-treated livers within the chronic model of CCl₄-induced liver fibrosis were immunoblotted for H3K36me3, H3K4me3, H3K27me3, H3K9me3, and β-actin. (B) Histological sections showing H3K27me3 staining in a representative set of vehicle or DZNep-treated chronic CCl₄ livers. Brown arrows show the presence of H3K27me3 staining in hepatocytes and biliary epithelial cells of vehicle-treated fibrotic livers, with H3K27me3 markedly absent in both cell types in DZNep-treated livers.