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. 2017 Jan 4;25(1):153–164. doi: 10.1016/j.ymthe.2016.10.002

Figure 3.

Figure 3

EV Vaccination Induced Less Activation of Astrocytes and Microglia in Young Tg2576 Mice (Preventive Study), but Not in Aged Tg2576 Mice (Therapeutic Study)

(A and B) Image analysis of hemibrains performed after immunostaining with anti-GFAP antibody (astrocytosis; A) and anti-MHC class II antibody (glial activation; B). (C) Number of vessels positive for amyloid deposits was calculated in the brains of experimental and control mice (scale bar, 50 μm). (D) Number of microhemorrhages in the hemibrains of vaccinated and control animals. Photomicrographs show representative images of hemibrain regions of immunized and control mice. Scale bars, 20 μm (A) and 50 μm (B–D). Error bars represent average ± SD (∗∗∗∗p < 0.0001).