Figure 4.

Immunization Design for Tg2576 Mice and Humoral Immune Responses Specific to β-Amyloid in Mice with or without Pre-existing Memory T Cells

(A) 6–6.5month-old Tg2576 mice were primed with adjuvanted Th epitope peptide (group 1; n = 9 and group 3; n = 8) or injected with adjuvant (group 2; n = 5) three times. After 3 months of resting, mice from groups 2 and 3 were immunized with EV, and group 1 (control group) was injected with adjuvant only. (B) Antibody responses were measured after the first immunization with EV. Lines indicate the average (^∗∗p < 0.01).