Cognitive Behavior of 15–15.5-Month-Old Tg2576 Mice with or without Pre-existing Memory Th Cells after Immunization with EV Vaccine
(A) Mice with pre-existing memory Th cells (n = 8) showed significantly increased recognition of novel object in novel object recognition task after immunization with EV compared to mice without memory Th cells (∗p < 0.05, n = 5) and control mice (∗∗p < 0.01, n = 9). (B) No significant changes in novel place recognition task performance were demonstrated regardless of presence or absence of pre-existing memory Th cells.