Figure 4.

Skin signatures applied in analysis for 18 skin conditions. The heatmap and dendrogram were derived from the log₂ fold change for each skin condition (test versus control group) for the 17 skin signatures on the left‐hand side of the dashed line. Expression of the remaining three signatures, apocrine gland, skeletal muscle, and Y‐chromosome, is highly dependent on sample properties unrelated to the condition (such as gender, contamination or sampling sites) and was therefore not included in the clustering. Full details of the datasets can be found in the supplementary material, Table S1. Significantly altered signatures (FDR ≤ 0.01 and ≥ 80% of the genes altered in the same direction) are indicated with a white dot. Due to the stated criteria for a comparison to be considered significant, there are instances where the average expression appears strongly dysregulated but is not considered significant; in these cases, it may be that FDR ≤ 0.01 but only < 80% of the signature is altered in the same direction. ^†Data for each skin condition derived from ref 3 were compared against the data for the same group of normal skin derived from multiple studies. ^‡Sampling designs for these studies may introduce an artificially‐altered balance between cell populations (such as complete removal of epidermis) in the test group, but not the control group. Further details may be found in the supplementary material, Table S1.