Table 1.

Key questions to address in the setting of heart transplant diagnostics identified by the panel

Microcirculation inflammation	Definition and multicenter assessment of MI grading system: Reproducibility—exportability, association with CAV, and outcome. Multicenter studies on MI phenotyping to assess the heterogeneity of MI and its relationship with ACR
Chronic antibody‐associated allograft damage	Assessment of the influence of persisting AMR on the cardiac vasculature from the epicardial arteries to the interstitial capillaries Systematically evaluate myocardial capillary density after repeated AMR episodes Ultrastructural studies to evaluate structural capillary changes after repeated AMR episodes Develop uniform terminology for describing the arterial lesions comprising CAV
Antibody detection in cardiac AMR	Connect antibodies to pathology in multicenter large‐scale studies Address anti‐HLA and non‐anti‐HLA‐Ab clinical relevance Assess Ab properties with injury phenotypes, CAV, and outcomes
Molecular approaches in heart TX	Molecular phenotype of AMR Connect antibodies and pAMR ISHLT categories with gene signatures in EMB Molecular phenotype of ACR

Ab, antibody; ACR, acute cellular rejection; AMR, antibody‐mediated rejection; CAV, cardiac allograft vasculopathy; ISHLT, The International Society for Heart & Lung Transplantation; MI, microvascular injury; pAMR, pathologic antibody‐mediated rejection; TX, transplant.