Table 1.
Participant Demographics and Baseline Characteristics
| Healthy Volunteers (n = 8) | Mild Hepatic Impairment (Child‐Pugh Class A) (n = 8) | Moderate Hepatic Impairment (Child‐Pugh Class B) (n = 8) | |
|---|---|---|---|
| Sex, n (%) | |||
| Female | 1 (12.5) | 2 (25.0) | 1 (12.5) |
| Male | 7 (87.5) | 6 (75.0) | 7 (87.5) |
| Race, n (%) | |||
| Black, African‐American | 3 (37.5) | 2 (25.0) | 1 (12.5) |
| White | 5 (62.5) | 6 (75.0) | 7 (87.5) |
| Age (years) | |||
| Mean (SD) | 45.9 (5.1) | 50.5 (4.4) | 49.8 (4.9) |
| Range | 39‐52 | 42‐55 | 42‐55 |
| BMI (kg/m2) | |||
| Mean (SD) | 28.4 (3.8) | 26.7 (3.1) | 28.7 (3.9) |
| Serum albumin (g/dL) | |||
| Mean (SD) | 4.2 (0.4) | 3.9 (0.3) | 3.5 (0.5) |
| Liver function | |||
| Mean (SD) AST (U/L) | 20.1 (4.8) | 48.8 (31.4) | 77.3 (45.1) |
| Mean (SD) ALT (U/L) | 21.9 (10.8) | 67.1 (45.5) | 64.0 (45.8) |
| Mean (SD) AP (U/L) | 60.6 (13.3) | 59.4 (8.1) | 113.0 (52.3) |
| Child‐Pugh score, median (range) | |||
| Median (range) | NA | 5 (5‐6) | 7 (7‐9) |
| History of viral hepatitis, n (%) | |||
| Yes | 0 | 8 (100) | 5 (62.5) |
| No | 8 (100) | 0 | 3 (37.5) |
| Serum IgG (mg/dL) | |||
| Mean (SD) | 1208 (322) | 1348 (460) | 1747 (474) |
| Unbound PCSK9 (ng/mL) | |||
| Mean (SD) | 322 (45) | 390 (73) | 343 (111) |
| Ultracentrifugation LDL‐C (mg/dL) | |||
| Mean (SD) | 121 (32) | 112 (31) | 96 (38) |
ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; BMI, body mass index; IgG, immunoglobulin G; LDL‐C, low‐density lipoprotein cholesterol; n, number of participants with the given characteristic; NA, not applicable; PCSK9, proprotein convertase subtilisin kexin type 9; SD, standard deviation.