Table 3.
Summary of Participants With Postbaseline AST >3 × Upper Limit of Normal Elevations
| Hepatic | ALT (U/mL) | AST (U/mL) | ||||||
|---|---|---|---|---|---|---|---|---|
| Impairment Group | Viral Hepatitis History? | Concomitant Medications During the Study | Baseline | Day 29 | Day 57 | Baseline | Day 29 | Day 57 |
| Moderate | No | Lactulose 60 mL/day | 45 | 60 | 45 | 98 | 126 | 56 |
| Spironolactone 25 mg/day | ||||||||
| Sertraline 100 mg/day | ||||||||
| Moderate | Yes | Furosemide 40 mg bid | 97 | 88 | 60 | 154 | 121 | 102 |
| Lactulose 10 g/day | ||||||||
| Pantoprazole 60 mg/day | ||||||||
| Phytonadione 5 mg bid | ||||||||
| Spironolactone 100 mg bid | ||||||||
| Rifaximin 550 mg tid | ||||||||
| Thiamine hydrochloride 100 mg/day | ||||||||
| Vitamin B6 100 mg/day | ||||||||
| Tramadol 100 mg prn | ||||||||
| Moderate | Yes | Metformin 500 mg bid | 164 | 130 | 121 | 130 | 110 | 82 |
| Mild | Yes | Hydrochlorothiazide 25 mg/day | 78 | 139 | 98 | 67 | 135 | 123 |
| Loratadine 10 mg/day | ||||||||
| Losartan potassium 50 mg/day | ||||||||
| Human insulin 70 U bid | ||||||||
| Clarithromycin 500 mg bid | ||||||||
ALT, alanine transaminase; AST, aspartate aminotransferase; bid, twice daily; prn, as required; tid, 3 times daily.