Figure 4.

Ant-134 Reduces Spontaneous Seizures after PPS-Induced Status Epilepticus in Rats

(A) miR-134 levels in rat hippocampus at “early” and “late” time points after PPS in comparison with the respective non-stimulated controls (p = 0.3309, n = 3–4/group). (B) Schematic illustrates PPS experimental design. (C) Representative EEG trace of a spontaneous seizure captured in a Scr-injected rat. (D–F) Individual rat (i–vi/vii) weekly seizure counts schematic (D) and graph (F) showing spontaneous seizures during long-term monitoring (8 weeks after the first spontaneous seizure). (E) Spontaneous seizure counts were summed by group. **p < 0.01 (for n = 6–7/group). All error bars shown as means ± SEM. ns, non-significant; SE, status epilepticus.