FIGURE 1.

Successful Dopamine D2 and D3 Receptor 2-Aminotetralin Agonists. Chemical structures of hydroxy-2-aminoteralin derivatives pursued as ¹¹C- and ¹⁸F-labeled imaging agents (a–g). Fluorine-18 labeled agonists include: 5-hydroxy-2-(N-propyl-N-(5-¹⁸F-fluoropentyl) aminotetralin (¹⁸F-5-OH-FPPAT, 2), 5-hydroxy-2-(N-propyl-N-(5′-¹⁸F-fluorohexyl)aminotetralin (¹⁸F-5-OH-FHXPAT, 3), and 7-hydroxy-2- (N-propyl-N-(5′-¹⁸F-fluorohexyl)aminotetralin (¹⁸F-7-OH-FHXPAT, 4)