Table 3.

Adjusted effects of diagnostic group on perfusion and structural MRI measures.

ROI	Cerebral blood volume rCBV		Cerebral blood flow rCBF		Gray matter volume		Cortical thickness
	β	p	β	p	β	p	β	p
Precuneus	−0.092	0.297	−0.276	0.001*	−0.052	0.548	−0.017	0.842
Inferior parietal	−0.154	0.081	−0.272	0.001*	0.049	0.562	0.021	0.804
Inferior temporal	−0.104	0.244	−0.269	0.002*	0.013	0.880	−0.011	0.897
Isthmus	−0.182	0.037	−0.285	0.001*	−0.068	0.436	−0.221	0.010*
Entorhinal	−0.063	0.475	−0.208	0.019*	−0.087	0.319	−0.236	0.005*
Hippocampus	0.032	0.718	0.017	0.845	−0.212	0.005*	NA	NA
Basal ganglia	−0.247	0.003*	−0.294	0.000*	−0.038	0.661	NA	NA

Effects of diagnostic group (HC = 105, MCI = 42) for cerebral blood volume, cerebral blood flow, gray matter volume, and thickness in regions-of-interest (ROIs). Statistical models were adjusted for sex, age, depression, and WML volumes. Standardized beta coefficients and p-values are reported. Asterisks indicate significance at p < 0.05, FDR corrected. Negative beta coefficients indicate hypoperfusion or gray matter atrophy in MCI patients.