Figure 3.

Lithium induces sustained postischemic neurological recovery. Mice were exposed to 45 min of intraluminal MCA occlusion and intraperitoneally treated with normal saline (control) or lithium (1 mg/kg bolus, followed by 2 mg/kg/day) starting at 6 h after reperfusion over up to 7 days. Neurological recovery was assessed using (a) rota rod, (b) tight rope, (c) corner turn, and (d) balance beam tests (n = 12–13 mice per group). *Significantly different from controls with p:0.009–0.021 (a), p:0.015–0.043 (b), p:0.024–0.032 (c), and p:0.014–0.046 (d).