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. 2016 Jul 20;37(3):980–993. doi: 10.1177/0271678X16648971

Figure 2.

Figure 2.

Delayed delivery of memantine at 20 mg/kg/d, but not 4 mg/kg/d promotes post-ischemic recovery of motor-coordination deficits. (a) Body weight, (b) LDF recordings above the core of the MCA territory, and (c and d) coordination skills evaluated by RotaRod and tight rope tests in animals exposed to transient MCAO. Vehicle or memantine (4 or 20 mg/kg/d) were subcutaneously administered over 28 d starting 72 h after reperfusion onset. Note the rapid improvement of coordination skills in animals receiving 20 mg/kg/d memantine. LDF recordings (a) and body weight (b) do not differ between groups. Results are means ± SD values (n = 18 animals/ group). Data were analyzed by two-way repeated measurement ANOVA, followed by two-tailed unpaired t tests for individual time-points. *p < 0.05, **p < 0.01 compared with ischemic vehicle.