Table 3.
Odds ratios (95% confidence intervals) and P-value (only with P≤0.1 shown) for the variables associated with perilesional hyperperfusion (PLH) at 24 h using bivariate logistic regression analysis.
| Variable | % of patients with hyperperfusion within 24 h | OR (95% confidence interval) | P > |z| |
|---|---|---|---|
| Baseline characteristics | |||
| Stroke severity at admission (unit increase) | 0.97 (0.9, 1.03) | 0.285 | |
| Thrombolytic treatment | 88.1 | 1.6 (0.55, 4.93) | 0.375 |
| Collateral grade (n = 151) | |||
| Good | 71.4 | 5.87 (2.56, 13.44) | <0.0001* |
| Poor/reduceda | 28.6 | 1 | |
| Aetiology (CCS classification) | |||
| Large artery atherosclerosis | 64.3 | 1.94 (0.9, 4.2) | 0.092 |
| Cardioembolic | 35.7 | 0.54 (0.25, 1.17) | 0.120 |
| Stroke topography (any infarction in given territory) | |||
| Infarction in cortical sup MCA territory | |||
| Present | 76.2 | 4.05 (1.75, 9.38) | 0.001* |
| Absenta | 23.8 | 1 | |
| Extent of cortical sup MCA infarction | 0.0032* | ||
| Complete | 42.9 | 3.37 (1.34, 8.48) | 0.010* |
| Partial | 33.3 | 5.47 (1.92, 15.6) | 0.001* |
| Absenta | 23.8 | 1 | |
| Infarction in striatocapsular territory | |||
| Present | 71.4 | 5.2 (2.29, 11.83) | <0.0001* |
| Absenta | 28.6 | 1 | |
| Extent of striatocapsular infarction | <0.00001* | ||
| Complete | 31 | 2.56 (1.01, 6.49) | 0.047* |
| Partial | 40.5 | 24.56 (6.19, 97.47) | <0.0001* |
| Absenta | 28.6 | 1 | |
| Clinical outcomes | |||
| NIHSS at 24 h (unit increase) | 0.92 (0.87, 0.98) | 0.014* | |
| Reperfusion status | 0.0035* | ||
| Major reperfusion | 80.95 | 5.33 (1.85, 15.34) | 0.002* |
| Partial reperfusion | 7.14 | 01.58 (0.32, 7.76) | 0.572 |
| No reperfusion | 11.9 | 1 | |
| Penumbral salvage | |||
| Yes | 76.19 | 3.64 (1.57, 8.44) | 0.003* |
| No | 23.81 | 1 | |
| Penumbral salvage volume (in ml) | 1.004 (0.998, 1.01) | 0.147 | |
| HT | 16.7 | 14.6 (1.73, 123.3) | 0.014* |
| HT classification | |||
| HI1 or HI2 | 16.7 | Predicts PLH perfectly. | |
| PH1 or PH2 | 0 | 1 | |
| ENI | 58.5 | 2.34 (1.08, 5.07) | 0.032* |
| mRS at 90 days | 0.86 (0.7, 1.05) | 0.132 | |
| Good (mRS = 0-2) | 61.9 | 1.5 (0.69, 3.2) | 0.297 |
| Bad (mRS 3–6) | 38.1 | 0.67 (0.31, 1.43) | 0.297 |
| Mortality (mRS = 6) | 2.38 | 0.16 (0.02, 1.32) | 0.09 |
HT: haemorrhagic transformation; mRS: modified Rankin Score; SCI: striatocapsular; sup MCA: cortical superior division middle cerebral artery.
Continuous or ordinal variables are shown as mean ± SD or median (IQR). Figures in parentheses are an interquartile range.
a
Used as reference category.
*
P < 0.05 as the threshold for statistical significance.