Figure 3.

Pioglitazone-recovered proteins in the APP vasculature. (a) Pioglitazone-rescued protein that (i) directly or indirectly interact with APP, and/or (ii) harbor known PPARγ-PPRE/PACM binding sites in their genomic sequences. (b) Average SOD1, XIAP, TPI1, RAB5C, and PPP1R9B peptide intensities for WT (green), WT(pio) (grey), APP (blue), and APP(pio) (red) mice.

Note: The function listed for RAB5C is probable, but not confirmed. Error bars denote standard error or SEM and ⋆ p < 0.05 denote significant interaction effect using two-way ANOVA. NO: nitric oxide; PIO: pioglitazone.